Effects of indomethacin on the metabolism of glycerol by rat-kidney tubules: an alternative explanation for the enhancement of glycerol-induced acute renal failure by indomethacin.
نویسندگان
چکیده
1. The metabolism of glycerol by isolated rat-kidney tubules was investigated. 2. Indomethacin, at a concentration of 0.1 mmol/l, markedly inhibited the utilization of glycerol and its conversion into glucose and CO2. 3. The glycerol 3-phosphate production rose significantly when indomethacin was present, indicating a fall in the rate at which glycerol 3-phosphate was oxidized. 4. The results are discussed in relation to the observation that indomethacin increases the severity of glycerol-induced acute renal failure.
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عنوان ژورنال:
- Clinical science
دوره 58 4 شماره
صفحات -
تاریخ انتشار 1980